The pathogenesis of Acanthamoeba keratitis
نویسندگان
چکیده
منابع مشابه
Pathogenesis of Acanthamoeba keratitis: carbohydrate-mediated host-parasite interactions.
Acanthamoeba keratitis is a sight-threatening corneal infection. In a recent study, the saccharide mannose has been shown to inhibit the binding of Acanthamoeba organisms to the epithelium of the cornea (L. D. Morton, G. L. McLaughlin, and H. E. Whiteley, Infect. Immun. 59:3819-3822, 1991). In an attempt to determine the molecular mechanism by which acanthamoebae adhere to the surface of the co...
متن کامل[Acanthamoeba keratitis].
Three patients, women aged 69, 25 and 30 years, with refractory keratitis were found to have a rare infection with Acanthamoeba. All wore soft contact lenses. The frequency of Acanthamoeba keratitis increased in recent years. At present, an efficacious antiprotozoal therapy is available, for instance in the form of polyhexamethylene biguanide and propamidine. In cases of refractory keratitis, t...
متن کاملAn update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment
Free-living amoebae of the genus Acanthamoeba are causal agents of a severe sight-threatening infection of the cornea known as Acanthamoeba keratitis. Moreover, the number of reported cases worldwide is increasing year after year, mostly in contact lens wearers, although cases have also been reported in non-contact lens wearers. Interestingly, Acanthamoeba keratitis has remained significant, de...
متن کاملPersistence of acanthamoeba antigen following acanthamoeba keratitis.
AIM To investigate the hypothesis that persistent corneal and scleral inflammation following acanthamoeba keratitis is not always caused by active amoebic infection but can be due to persisting acanthamoebic antigens METHODS 24 lamellar corneal biopsy and penetrating keratoplasty specimens were obtained from 14 consecutive patients at various stages of their disease and divided for microscopy...
متن کاملLaboratory investigation of Acanthamoeba keratitis.
Following the diagnosis of Acanthamoeba keratitis in a contact lens wearer, the antimicrobial susceptibility of the clinical isolate and the environmental source of the infection were investigated. Contrary to previous reports, in vitro antimicrobial testing showed that the infecting strain was inherently resistant to propamidine isethionate. Restriction endonuclease digestion analysis of Acant...
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ژورنال
عنوان ژورنال: Australian and New Zealand Journal of Ophthalmology
سال: 1991
ISSN: 0814-9763,1440-1606
DOI: 10.1111/j.1442-9071.1991.tb01794.x